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In vitro , GSH-deficient hepatocytes show upregulated mRNA levels of DNA methyltransferase, Tet2, and Tet3, along with increased Dnmt activity (5-mC) and global DNA methylation levels

This reaction can generate more toxic radicals through interactions between the superoxide (SO) anion and hydrogen peroxide (H 2 O 2 ) [12, 13]

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