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individual results vary significantly

It notes that semaglutide was present in the milk of lactating rats, but adds that due to species-specific differences in lactation physiology, the clinical relevance of these data is not clear

There was a significant inverse correlation between plasma GLP-1 concentration shortly after a meal and plasma glucose concentration 2 hours post-prandially, coinciding with the plasma glucose nadir

Best practices include: Setting realistic expectations at initiation Documenting and tracking tolerability Adjusting or switching medications based on response Collaborating with dietitians and other care team members Supporting your patients through each stage of therapy leads to greater confidence and continuity

Blundell J et al

Every trial arm except one used this as the entry point, and for good reason