The rationale is that glucagon also increases energy expenditure and promotes hepatic fat mobilization, so a molecule that combines glucagons metabolic-rate effect with GLP-1/GIPs appetite-and-glucose control can, in principle, drive weight loss from both sides of the energy-balance equation at once
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While semaglutide is not currently listed as causing allodynia in FDA prescribing information, patients with diabetes may already be at risk for nerve pain from their underlying condition
Funding This work was supported by grants from the National Natural Science Foundation of China (81971933, 81770592, and 81671570), National Science and Technology Major Project of China (2017ZX10202202-004 and 2018ZX10301202)
Bernard, W
