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Overall, at week 88, participants with 75% or more weight regain after tirzepatide withdrawal reversed cardiometabolic parameters to baseline (week 0) values, the team write, although they note those with up to 50% weight regain still showed improvements in these areas compared with the start of the study

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Also, the data was calculated based on people with at least one weight-related comorbidity like hypertension or cardiovascular disease after 68 weeks

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Hafez SMNA, Elbassuoni E, Abdelzaher WY, Welson NN, Batiha GES, Alzahrani KJ, Abdelbaky FAF (2021) Efficacy of vitamin E in protection against methotrexate induced placental injury in albino rats