In the analysis, HRV dropped after treatment and stayed relatively flat across both absolute exercise duration and exercise relative to a 7-day rolling baseline
In the TRIUMPH-4 Phase 3 trial, the most common adverse events for the 12 mg dose were nausea (43.2%), diarrhea (33.1%), constipation (25.0%), vomiting (20.9%), and decreased appetite
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Retatrutide is being studied because its three-receptor design may affect appetite and energy metabolism in broader ways
Given this undesirable effect, several niacin derivatives with prolonged release time, including enduracin, niaspan and acipimox, have been developed