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It standardizes study design, PK parameters, and BE acceptance criteria across ICH regions (US, EU, Japan, Canada)

Small intestinal mucin is less dense and penetrable to bacteria

1 ml of 50 mM potassium phosphate buffer (pH 7.0), containing 10% (w/v) polyvinylpyrrolidone (PVP), 0.25% (v/v) Triton X-100, 1 mM phenylmethylsulfonyl fluoride (PMSF) and 1 mM ASA were added in a homogenate of 100 mg (FW) of leaf tissues to measure glutathione reductase (GR, EC 1.6.4.2), dehydroascorbate reductase (DHAR, EC 1.8.5.1), and monodehydroascorbate reductase (MDHAR, EC 1.6.5.4)

Primer sequences for qRT-PCR are shown in Supplementary Table S2

i vi cc tnh trng bnh nhn nghim trng hn th dng: t 600 n 1200 mg/ngy

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