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Due to the highly amyloidogenic nature of endogenous human insulin, researchers took inspiration from the proline residues in rat insulin, which are highly homologous but not amyloidogenic (known to disrupt the secondary structure), and incorporated them into the human insulin sequence to develop Pramlintide

Abedini S, Namdari R, and Law FCP

Evening intake of alcohol, caffeine, and nicotine: night-to-night associations with sleep duration and continuity among African Americans in the Jackson Heart Sleep Study

The NorthStar Ambulatory Assessment in Duchenne muscular dystrophy: considerations for the design of clinical trials