Nature (2007) 7
However, its effect is due to fibernot through a pharmacologically strong GLP-1 effect
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Due to the actions of GLP-1, beta cells secrete increased amounts of insulin in response to ingested glucose when compared to the same concentration of glucose injected intravenously (13), a phenomenon described as the incretin effect(14)
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When you inject semaglutide, the medication circulates through your bloodstream and crosses the blood-brain barrier, where it binds to GLP-1 receptors in the arcuate nucleus and other hypothalamic regions