Quality of unregulated supply is also a real, separate risk
Ferroptosis terminates with mitochondrial dysfunction and toxic lipid peroxidation
NF-B is a central regulator of pro-inflammatory gene expression
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Recently, pyruvate metabolism has been associated with GSH metabolism and ferroptosis in lung cancer cells through the plasma membrane cysteine transporter SLC7A11 [91] (ranked 3rd by GSH metabolic process GO term annotation probability in RF classifiers)
Abbreviations 1 H NMR: 1 H Nuclear Magnetic Resonance ALT: Alanine Aminotransferase ARE: Antioxidant Response Element AREG: Amphiregulin AST: Aspartate Aminotransferase BIRC5: Baculoviral IAP Repeat Containing 5 BP: Biological Process BUN: Blood Urea Nitrogen CC: Cellular Component CCL3: Chemokine (C-C motif) ligand 3 CMC: Critical Micelle Concentration CLSM: Confocal Laser Scanning Microscope CREA: Creatinine CXCL1: CXC chemokine ligand 1 DAB: 3,3-Diaminobenzidine DCs: Dendritic Cells DEGs: Differentially Expressed Genes DLS: Dynamic Light Scattering DSC: Differential Scanning Calorimetry EPGN: Epithelial Mitogen (Epigen) FC: Fold Change FDR: False Discovery Rate Foxe1: Forkhead box E1 FTIR: Fourier Transform Infrared Spectroscopy GAPDH: Glyceraldehyde-3-phosphate Dehydrogenase GO: Gene Ontology GPP: Generalized Pustular Psoriasis GSEA: Gene Set Enrichment Analysis GSH: Glutathione HA: Hyaluronic Acid H&E: Hematoxylin and Eosin HRP: Horseradish Peroxidase IC 50 : Half-maximal Inhibitory Concentration IFN-: Interferon- IF: Immunofluorescence IHC: Immunohistochemistry IL: Interleukin IMQ: Imiquimod JAK: Janus Kinase KEGG: Kyoto Encyclopedia of Genes and Genomes LATS1: Large tumor suppressor homolog 1 LPS: Lipopolysaccharide LSD: Least Significant Difference MAPK: Mitogen-activated Protein Kinase MF: Molecular Function MST1: Mammalian Sterile20-like Protein Kinase 1 NF-B: Nuclear Factor-Kappa B Nrf2: Nuclear Factor Erythroid 2-Related Factor 2 OA: Oleanolic Acid OA-NPs: OA-grafted HA Prodrug Nanoparticles PASI: Psoriasis Area and Severity Index pDCs: Plasmacytoid Dendritic Cells PDI: Polydispersity Index PI: Propidium Iodide PLAU: Plasminogen Activator, Urokinase RAR: Retinoic Acid Receptor SC: Stratum Corneum SEM: Scanning Electron Microscopy SPF: Specific Pathogen-free STAT3: Signal Transducer and Activator of Transcription 3 TAZ: Transcriptional Co-Activator With PDZ Binding Motif TCM: Traditional Chinese Medicine TEM: Transmission Electron Microscopy TGA: Thermogravimetric Analysis TLR7/8: Toll-like Receptors 7 and 8 TNF-: Tumor Necrosis Factor- UA: Uric Acid UV-Vis: Ultraviolet-Visible Spectroscopy XRD: X-Ray Diffraction YAP: Yes-Associated Protein -GT: -Glutamyl Transferase References Liu S, He M, Jiang J, Duan X, Chai B, Zhang J, et al
