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Restricting calorie intake results in several acute changes, including increases and decreases in the appetite hormones ghrelin and leptin, which may lead to low energy and heightened hunger

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The M1 phenotype is often associated with disease, resulting in production and secretion of pro-inflammatory cytokines (i.e., tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1), and IL-6), chemokines, and ROS to neutralize pathogens and increase cell recruitment to the site of inflammation

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These diets emphasize fruits, vegetables, whole grains, fish, and healthy fats, while limiting processed foods, added sugars, and saturated fats (72)

Spatial memory is the part of the memory that is responsible for recording the environment and one's spatial awareness to it