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As damage from smoking or even pollution accumulates to the respiratory tract and the lungs, oxygen and carbon dioxide (CO2) exchange suffers, making it difficult to breathe

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Horm Res 43:286293 [DOI] [PubMed] [Google Scholar] Spickett CM, Wiswedel I, Siems W, Zarkovic K, Zarkovic N (2010) Advances in methods for the determination of biologically relevant lipid peroxidation products

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Furthermore, a high TMAO level is considered an indicator of an increased disease risk in the future (Canyelles et al., 2018)

The gain-of-function mutations of IDH1 and IDH2 genes commonly occur in GBM and acute myeloid leukemia (AML) and are associated with accelerated tumor cell proliferation and inhibited differentiation [75,76]