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Some studies suggest that some traditional medicine-derived interventions may ameliorate fatigue-related central abnormalities by modulating HPA axis activity, oxidative stress, mitochondrial function, BDNF-related signaling, and monoaminergic neurotransmission (Surapaneni et al., 2012

Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances