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A recent systematic review identified 33 registered trials looking at GLP-1s for SUDs, predominantly for alcohol and nicotine, but with growing interest in opioid and stimulant SUDs

doi: 10.1161/CIRCULATIONAHA.124.067676 40 XiangJQinLZhongJXiaNLiangY

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Cardiovascular Outcomes - Patients with T2DM and Atherosclerotic CVD The incidence of major cardiovascular events with TRESIBA was evaluated in DEVOTE

One plaintiff reported vomiting multiple times a day after using Wegovy, while another claimed her teeth fell out due to excessive vomiting

Notable interactions include: Diuretics (furosemide, spironolactone) Insulin or insulin secretagogues (sulfonylureas) Lithium Alcohol Recommended dose Start with 10 mg once daily in the morning, with or without food