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Compared with placebo, tirzepatide provided an additive body-weight loss of 11.9%, 16.4% and 17.8% with an increasing dose of 5 mg, 10 mg and 15 mg, respectively, and 83.5% of participants in the 15 mg group had 10% body-weight loss [28]

During ferroptosis, the most obvious changes in mitochondria are morphological alterations, such as mitochondrial shrinkage, increased membrane density, and diminished or absent mitochondrial ridges [14]

Immediate discontinuation and treatment may be required if these reactions occur

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10.1016/j.pbb.2006.09.008 Pharmacol Biochem Behav