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D., & Muscat, J

Alfonso-Prieto M, Biarns X, Kumar M, Rovira C, Kozlowski PM

C-reactive protein promotes the expansion of myeloid derived cells with suppressor functions

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195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death

Pissimissis, N., Papageorgiou, E., Lembessis, P., Armakolas, A