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Similar to 2-AR, PAR2 triggers intracellular signaling through G-protein-dependent mechanisms

This suggests that ferroptosis, in conjunction with pyroptosis ( via NLRP3), may regulate atherosclerosis progression, offering insights into potential therapeutic targets for CAD ( 4.1.4 Non-coding RNAs as biomarkers for ferroptosis in CAD Beyond protein-based biomarkers, non-coding RNAs have emerged as ferroptosis biomarkers relevant to CAD