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doi: 10.1016/j.cbpc.2024.109991, 91

This is achieved by two engineering tricks: non-proteinogenic (non-natural) amino-acid substitutions near the N-terminus that sterically block the enzyme, and acylation with a fatty diacid that gives reversible binding to plasma albumin and dramatically extends circulation time

Lifestyle considerations: While dietary B12 intake is not relevant in pernicious anaemia (due to malabsorption), maintaining a balanced diet supports overall health

Akin to a night at the Oscars, without insurance, the medication can cost around $1,000 per month

2010 doi: 10.1089/ars.2008.2282

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