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In conclusion, GLP-1 receptor agonists effectively alleviate hepatic inflammation in MASLD by suppressing pro-inflammatory cytokine release, inhibiting NF-B signaling, modulating the phenotypes of immune cells, and reducing the activation of inflammasomes

Systemic blocking of ANGPTL4 poses many risks and is a challenge for new therapies (Dewey et al., 2016)

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[10] Sitagliptin was developed by Merck & Co