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Saxena AR, Frias JP, Brown LS, et al

This includes affecting metalloproteinases (MMPs) and their inhibitors

However, BDF treatment notably upregulated c-kit expression, likely due to its protective effects on intestinal wall cells, as BDF also repaired the damaged intestinal barrier in rats

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It also leads to violations of RBCs shape and volume and impairs their transport in microchannels

These features are essential for oxygen transport, since RBCs have to undergo repeated shape changes without fragmentation, to assure their passage and oxygen perfusion through all vascular networks, namely, through capillary blood vessels with smaller lumen diameter than that of RBCs [6, 7]