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N- and C- terminal modifications of Nle 1 -AnglV-derived peptides exhibit improved stability in rat serum Devleopmen of a metabolically stable, BBB permeable Nle

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Methanolic leaf extracts of Hawaiian kava cultivars showed stronger binding inhibition to several CNS receptorsincluding GABA A , dopamine D2, opioid (, ), and histamine (H1, H2)than root extracts, suggesting that compounds beyond the main kavalactones may contribute to the pharmacological effects of kava leaves

2011), myocardial infarction (Merabet et al

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