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Based on the results, ten Kulve and colleagues (2015) argue that endogenous GLP-1 is involved in satiating effects after meal intake in obese patients with T2D (ten Kulve et al

To establish the importance of the NEP-derived metabolite GLP-1(2836) to the overall cardiovascular biology of GLP-1, we used sacubitril, a pharmacological inhibitor of NEP, and assessed in vitro cAMP accumulation in caSMCs, as well as functional LVDP recovery in an ex vivo Langendorff model of IRI

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10.1111/bph.15647 11 BossartM.WagnerM.ElvertR.EversA.HbschleT.KloeckenerT.et al (2022)