Executive Vice President & President, Lilly Cardiometabolic Health, Eli Lilly and Company Why this matters 1 Triple agonist = next-gen metabolic therapy Mimics GLP-1, GIP, and glucagon multi-pathway metabolic control 2 Diabetes + obesity convergence Simultaneous A1C + weight control = major unmet need solved 3 Competitive landscape shift Raises the bar vs GLP-1 mono & dual incretin therapies 4 No plateau signal is critical Suggests longer-term sustained efficacy Safety profile (expected class effects) Nausea, diarrhea, vomiting (dose-escalation phase) Discontinuation rates relatively low (25%) My takeaway 1 Metabolic disease treatment is entering multi-hormone era 2 Obesity + diabetes becoming one therapeutic category 3 Efficacy approaching bariatric-level outcomes 4 Sets new benchmark for Novo Nordisk and competitors Bottom line: Retatrutide isnt just competing Its redefining how we treat metabolic disease at the systems level #Diabetes #Obesity #GLP1 #Biotech #ClinicalTrials #Pharma #Innovation To view or add a comment, sign in 2,706 followers
Mothers can begin treatment as soon as their physician confirms they are appropriate candidates based on BMI and health status
The researchers suggest that chewing more may help people keep their weight down
Science Spyglass GLP-1 receptor assay: drug discovery in the metabolic disorders field Metabolic disorders , particularly type 2 diabetes and obesity , represent a major global health burden
Results suggested that levocarnitine consumption can decrease the dose of erythropoiesis-stimulating agent (ESA) required in patients with renal anemia regarding hemodialysis, and amend response to ESA therapy (Maruyama et al., 2017)
7.3 2.9 ng/ml)
