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Zinc ions modulate protein tyrosine phosphatase 1B activity

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Many people experience side effects during titration that prevent them from reaching the therapeutic dose

Rizzo, The Emerging Role of Dual GLP-1 and GIP Receptor Agonists in Glycemic Management and Cardiovascular Risk Reduction, Diabetes Metabolic Syndrome and Obesity

Using fatty acids to prolong the duration of the action of peptides and proteins was already a long established technique at Novo Nordisk and elsewhere and had been successfully applied to insulin (insulin detemir) (Knudsen, Lau)