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Aghdasi B, et al

Under healthy conditions, the body will repair or destroy the cell

Preclinical studies have found that the development of post-traumatic OA is delayed after local clearance of senescent cells in the articular cartilage of p16-M3R transgenic mice [14], and anti-senescence drugs (i.e., senolytics) also show potential in OA treatment [15,16,17]

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Antibodies specific for ACTL6A (Abcam, ab3882, 1:4000), GCLC (Abcam, ab190685, 1:4000), anti-NRF2 (Cell Signaling Technology, 12721 s, 1:2000), flag-tag (Sigma, F1804, 1:5000), and GAPDH (Proteintech, 10494-1-AP, 1:5000) were purchased from the indicated companies

This interaction effectively silences multiple small interfering RNAs and subsequently ushers in the era of VSMC senescence and calcification (82)