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However, this overall benefit reflects predominantly positive results from specific agents, with important exceptions such as lixisenatide in the ELIXA trial, which demonstrated cardiovascular safety but no significant reduction in MACEs (HR = 1.02, 95% CI 0.891.17) [86]

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In fact, some studies have shown that intermittent fasting can help obese adults lose weight, with minimal effort involved in counting calories or restricting specific foods