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Finally, we showed that dehydroascorbate labeled for positron emission tomography, namely [1- 11 C]dehydroascorbate, showed no change in brain signal accumulation after diethyl maleate treatment

This leads to the reduction of oxygen by electrons from the heme group with subsequent production of superoxide radical (O 2 -) [150]

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Neuropharmacology 2018;133:23341

Multiple reports have described clinical improvement of HS following weight loss with other medical interventions, such as dietary measures and bariatric surgery