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L-theanine intake (6 mg/kg) could prevent brain atrophy and stress vulnerability in senescence-accelerated mice prone 10 (SAMP10) mice, with the mechanism of intaking L-theanine could block the expression changes of the transcription factor neuronal PAS domain protein 4 ( Npas4 ) and Lipocalin 2 ( Lcn2 ) in hippocampus and PFC of SAMP10 (58)