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no hepatic safety signal has been observed across the orforglipron clinical program, distinguishing it from the discontinued Pfizer oral GLP-1 candidates lotiglipron and danuglipron, both of which were terminated due to liver toxicity concerns

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When used appropriately and under a physician's supervision, they can support long-term metabolic health and sustainable results

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Newsome P.N., Buchholtz K., Cusi K., Linder M., Okanoue T., Ratziu V., Sanyal A.J., Sejling A.S., Harrison S.A., NN9931-4296 Investigators A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis