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Increased HSP90 expression has been observed in MASLD, where it contributes to lipid imbalance and metabolic dysfunction

In terms of antioxidant capacity, YTHDF1 knockdown significantly reduced MDA levels and elevated SOD and GSH-PX activities, however, SLC7A5 overexpression reversed these beneficial changes (Fig

Several mechanisms have been reported for the increased activity of NRF2 in cancers ( Figure 5 ): (1) somatic mutations in KEAP1 or NRF2 , (2) DNA hypermethylation at the promoter region of KEAP1 , (3) the aberrant accumulation of proteins that disrupt the KEAP1NRF2 interaction, (4) transcriptional up-regulation of NRF2 gene through oncogene-dependent signaling, and (5) the modification of KEAP1 protein through oncometabolites

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Growth-modulating plasma tripeptide may function by facilating copper uptake into cells

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