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This inhibitor substantially decreased the number of cells in adherent and spheroid cultures as well, nevertheless it has increased their tumorigenic potential as determined by higher frequency of tumor-initiating cells in vivo

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4-OHE2 itself is an estrogen receptor ligand slower glutathione clearance of 4-OHE2-derived reactive species extends both their genotoxic and their receptor-activating potential at target tissues

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Mitochondrial protection by resveratrol

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