At neomycin concentrations of 100, 200, and 400 M either inhibitor demonstrated partial attenuation of Dihexa otoprotection, indicating at least partial reliance on their associated signaling proteins for protective effects (Figure 6A)
This is because E2 production by the follicles in the ovaries is inhibited due to the inhibitory effect of the COC on follicle stimulating hormone (FSH) production, which normally results in follicular maturation
Jonderko, K., Jonderko, G
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J Appl Microbiol (2014) 116:162131