Pharmacological mechanism Tirzepatide is a synthetic peptide which mimics the dual action of the natural incretin hormones: Glucose-dependent Insulinotropic polypeptide (GIP) Glucagon like-peptide-1 receptor agonist (GLP-1 RA) GIP and GLP-1 RA are released in the gut in response to the nutrients present in the food
Over up to seven years of follow-up, those treated with semaglutide or tirzepatide had a 37% lower risk of developing dementia (hazard ratio [HR] 0.63, 95% CI 0.500.81), a 19% lower risk of stroke (HR 0.81, 95% CI 0.700.93), and a 30% lower risk of all-cause mortality (HR 0.70, 95% CI 0.630.78), compared to those on other antidiabetic drugs
This evidence collectively helps build a strong case by demonstrating the drugs harmful effects, the failure of the manufacturer to provide adequate warnings, and the resulting damages suffered by the patient
Discuss any severe gastrointestinal history with your doctor
10.7717/peerj.1265 471 PerrinF
These actions require the sustained generation of ATP by oxidative phosphorylation