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Patients in the phase 3b clinical trial maintained about 75-80% of their weight loss and health benefits, such as reduced waist circumference and improvements in blood pressure, blood sugar, triglycerides and cholesterol levels

Although their precise mechanisms of action remain to be completely elucidated, it has been reported that HCQ inhibits the mitochondrial antioxidant system induced by TCR crosslinking, consequently increasing mROS levels and reducing CD4+ T cell proliferation through oxidative stress (173)

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Notably, mutation of E 115 inactivates CHAC1, preventing GSH depletion in vivo (Kumar et al., 2012)

Ipamorelin is a synthetic peptide that stimulates the release of growth hormone by targeting specific receptors in the pituitary gland