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2016
The active ingredient in Alli is known as orlistat
10.1093/annonc/mdv027 41 FujiwaraM.IzuishiK.SanoT.HossainM
Semaglutide is a highly potent GLP-1 receptor agonist, and increasing beyond 2.4 mg produces diminishing returns with increasing side effects
It is not a perfectly flat line a daily shot gives a broad peak then a decline but it is more sustained and less pulsatile than natural secretion, and it triggers IGF-1 and somatostatin feedback that dials your own pituitary down while treatment continues
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