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A serum APAP concentration (measured at least 4 hours after ingestion) resulting in a value above the lower line of the nomogram necessitates a full course of NAC therapy (eg, standard oral loading dose of 140 mg/kg of NAC followed by 70 mg/kg every 4 hours for 17 oral doses) be delivered

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The mechanism involves activating the pituitary gland through pathways like protein kinase C (PKC) and phospholipase C (PLC), which promotes the release of growth hormone (GH) into the bloodstream

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its PK characteristics should match the rate of carbohydrate delivery since a mismatch might result in hypoglycemia

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