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The approval is supported by the OASIS clinical trial programme, where participants achieved around 17% average weight loss, with nearly one in three losing 20% or more, alongside lifestyle intervention

Tirzepatide vs insulin Lispro added to basal insulin in type 2 diabetes: the SURPASS-6 randomized clinical trial

They slow stomach emptying and increase fullness, which reduces appetite and calorie intake, leading to gradual weight loss

Furthermore, L-carnitine upregulates genes involved in fatty acid transport and mitochondrial -oxidation ( Octn2, Cpt1a, Cpt2, Acadm ) while increasing metabolites associated with TCA cycle, urea cycle, and antioxidant pathways (malate, citrulline) (45)

the share of patients with a history of eating disorders