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The growth hormone secretagogue peptides (CJC-1295, Ipamorelin, GHRP-6) are used in bodybuilding communities partly because elevated HGH supports muscle retention and recovery

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Intriguingly, genetic variations with reduced IIS due to SNPs of interacting components of the IIS cascades ( GH1, IGF1, IGF1R, IRS1, FoxO1A, FoxO3A ) and have been associated with increased longevity [30, 31]

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