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To date, Phase 3 clinical trial data have also shown significant weight-loss outcomes, including up to 28.7% average body weight loss at 68 weeks in one obesity trial and 16.8% average weight loss at 40 weeks in adults with type 2 diabetes, with additional Phase 3 readouts still expected throughout 2026

doi:10.4055/cios23213 Barber FA, Howard MS, Ashraf W, Spenciner DB

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Avoid taking Benadryl if you or a family member are allergic to diphenhydramine, have hypersensitivity, have a lower respiratory tract disease such as asthma, routinely use a local anesthetic, or are currently nursing

This process is referred to as substrate-level phosphorylation