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Semaglutide achieves greater HbA1c and weight reduction, while SGLT2 inhibitors provide larger albuminuria declines in early diabetic nephropathy

The three modifications included: amino acid substitution at position 8 changing alanine to alpha-aminoisobutyric acid, and position 34, changing lysine to arginine, as well as acylation of the lysine in position 26 with a spacer and a C-18 fatty acid chain

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For the UK healthcare system, this suggests a future where pharmacotherapy could reduce the downstream need for liver transplants and specialized hepatology services

2019;9(3):e12310

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