glp-1 dual agonist GIP/GLP-1 receptor agonists: New advances for treating type-2 diabetes Frontiers | Clinical perspectives on

Ban N, Takahashi Y, Takayama T, Kura T, Sakamaki S, Niitsu Y (1996) Transfection of glutathione S-transferase (GST)- antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide

Mol Metab 34:27

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Absorbance was measured at 450 nm and 37 C in a CLARIOstar Plus Microplate (BMG LABTECH) using kinetic mode with measurements every 1 min for 45 min

It is an imbalanced agonist with GIPR potency close to native GIP but weaker GLP-1R affinity, and shows biased GLP-1R signaling, favoring cAMP over -arrestin recruitment

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