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Nicotine acts on acetylcholine receptors in the brain and increases release of feel good neurotransmitters like serotonin, dopamine and norepinephrine

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P.g disrupts gut linoleic acid (LA) metabolism, activates Th17, suppresses Tregs, and exacerbates colitis, and these effects could be reversed by LA supplementation (Jia et al., 2024)

In PD, dopamine deficiency results in motor symptoms and Mucuna pruriens may alleviate these symptoms by increasing dopamine levels

In the case of oxidative stress, JNK increases the phosphorylation of SARM1, resulting in enhanced NAD + degradation activity, which in turn promotes the suppression of mitochondrial respiration