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These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance
Noting the medications original intended use as well as the KFF survey on ever and current use reasons, Gateway Health Alliances Kothari adds that general weight management, including lifestyle and cosmetic purposes, continue to increase
Older adults sometimes experience side effects more intensely and might need longer adjustment periods
It acts on three hormone pathways: GIP, GLP-1, and glucagon
Retatrutide extends this further by incorporating GCGR activation, adding a third metabolic lever that directly increases energy expenditure
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