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Therefore, in addition to L-carnitine for mitochondrial fatty acid transport, ALCAR provides acetyl-CoA that can be used for brain lipid synthesis, be oxidized in the citric acid cycle for energy production, or be incorporated into neurotransmitters such as acetylcholine [3639].* ALCAR has shown several benefits for brain health: it supported brain energy metabolism, brain mitochondrial function, neuronal membrane lipid/phospholipid metabolism, synaptic plasticity, and neuroprotective functions [4056]

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doi: 10.1016/j.canlet.2018.04.021 13 MatiasCBelnapDWSmithMTStewartMGTorresIFGrossAJet al

Interestingly, the prenatal inhibition of GABAergic signaling with GABA receptor antagonists, such as picrotoxin administration on E10-12, suppressed neurogenesis in the fetal brain (97) and resulted in ASD-like social deficits in offspring (97, 98)