These changes are often linked to weight loss, but researchers believe there are other mechanisms at play
Most GLP-1 injections are given once weekly as a subcutaneous (under the skin) shot
Importantly, demand is no longer limited to diabetic patients
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This has actually been measured directly: researchers analyzed real human skin biopsies (ages 15 to 77, plus newborns) and found NAD+ dropped significantly with age, alongside more DNA damage and slower repair activity in that same tissue, across the age range studied
Similar to the VTA, analysis of excitatory transmission shows that GLP-1r stimulation primarily changes presynaptic measures of release probability, again indicating a presynaptic GLP-1r localization(Mietlicki-Baase et al., 2014)