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Potential immune sensitization: If degraded peptide fragments trigger antibody production, your body might become less responsive to semaglutide itself

This mechanistic advantage provides greater clinical confidence that it can achieve and sustain significant weight reduction

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Before getting started on the medication, make sure to complete a comprehensive health assessment to find out your bodys current vitamin levels, kidney and liver function, and sensitivity to the active ingredients

However, semaglutide and tirzepatide will likely remain appropriate first line options for patients with less severe obesity or those who prefer established medications with longer safety track records

Vibration controlled transient elastography (VCTE) is most commonly used methods to assess for fibrosis, with liver stiffness measurements less than 8 kPa used to rule out advanced fibrosis