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Contraindications include a personal or family history of medullary thyroid carcinoma (MTC), multiple endocrine neoplasia syndrome type 2 (MEN 2), or a known allergic reaction to the medication

[5] [6] Any use in the UK would therefore involve an imported unlicensed medicine, with full clinical and legal responsibility resting with the prescriber

The compound activates the GIP receptor (glucose-dependent insulinotropic polypeptide), the GLP-1 receptor (glucagon-like peptide-1), and the glucagon receptor simultaneously [1]

When GLP-1 binds to GLP-1R, it: Stimulates insulin secretion in the pancreas to regulate blood glucose levels

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9 Foods and Supplements That Increase GLP-1 Naturally Jocelyn McTavish Oct 1, 2025 8 min read Updated: Apr 21 Written by Nicole Rowe, MD | Reviewed by Katie E