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The discrepancy could be due to the difference in cell models and the high rapamycin concentration (100 nM) used in that study which may have induced cell stress 24

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doi: 10.3389/fpsyt.2023.1249578 Received 28 June 2023 Accepted 30 August 2023 Published 02 October 2023 Volume 14 - 2023 Edited by Jeffrey C

MartCarvajal et al., 2019)

Mechanistic Research Perspective Investigation of intracellular signaling pathway modulation Analysis of receptor-mediated peptide interaction mechanisms Evaluation of growth factor responsiveness in cellular systems Gene transcription and molecular regulation research Integration into mitochondrial ATP production and metabolic pathway studies Primary Research Applications Cell Biology and Regenerative Models: Used in controlled cellular models to study signalling behaviour, adaptive responses, and peptide-driven molecular communication