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The selectivity of FOXO4-DRI for senescent over non-senescent cells is mechanistically grounded: FOXO4 is expressed at low levels in most non-senescent adult cells, but is strongly upregulated in senescent cells

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By addressing the complex interplay of forces and molecular processes that contribute to ACL injuries, it is possible to improve outcomes for individuals at risk of or recovering from these debilitating injuries (Table 2)

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