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Body composition changes, like reduced bloating, slightly looser clothing, or feeling less puffy, often appear before the scale reflects significant fat loss

Diabetes-Metab Res (2016) 32(8):84357

Achieving these outcomes with a second obesity medication may indicate a broader efficacy trend for pairing these two classes of medications." Menopause-related hormonal changes often result in increased abdominal fat, decreased muscle mass and altered energy expenditure, which leads to weight gain and puts millions of women at risk for developing heart disease and other serious health issues

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