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That is the share of total weight lost that registered as lean mass on the body-composition scans in STEP-1, the landmark semaglutide trial published in the New England Journal of Medicine in 2021
Every body responds to treatment differently, but most patients begin to notice a difference in their energy levels and appetite within the first few weeks
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Why diet and exercise alone may not work Diet and exercise have long been the gold standard in turning the tide on weight gain, though genetics, medical conditions and socioeconomic factors can make losing weight difficult to impossible
However, it is important that patients understand this is not a milder version of the medication
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